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KMID : 0043319870100030153
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Archives of Pharmacal Research
1987 Volume.10 No. 3 p.153 ~ p.157
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Synthesis of Imidazole Derivatives Containing Biologically Active Units
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Elagamey AGA
Harb AFA/Khodeir MN/Sowellim SZA
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Abstract
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Reaction of oxazolin-5-ones 1 with p-amino-diphenylamine was resulted in the formation of the corresponding imidazolin-5-ones 2 which on treatment with sulphur afforded phenothiazines 3. Acridine derivatives 5 were obtained from acetylaminodiphenyl-amines derivatives 6 on heating with ZnCl2 at 200oC. 3 reacted with chloroacetyl chloride to give 7 which reacted in turn with different amines to give 8. Antibacterial activity of the obtained products was studied.
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